Pertuzumab - Genentech/Roche
Alternative Names: Anti-2C4 monoclonal antibody; Omnitarg; Perjeta; R-1273; RG-1273; rhuMab-2C4; rhuMAb2C4; Ro 436-8451/F01; RO-4368451-F01; RO4368451Latest Information Update: 14 Mar 2025
At a glance
- Originator Genentech; Roche
- Developer Chugai Pharmaceutical; Dana-Farber Cancer Institute; FONDAZIONE DEL PIEMONTE PER L'ONCOLOGIA IRCC DI CANDIOLO; Genentech; Japan Breast Cancer Research Group; Medica Scientia Innovation Research; Roche; West German Study Group
- Class Antineoplastics; Immunotherapies; Monoclonal antibodies
- Mechanism of Action Antibody-dependent cell cytotoxicity; Dimerisation inhibitors
-
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Breast cancer
- Phase III Ovarian cancer
- Phase II Brain metastases; Colorectal cancer
- Phase I HER2 positive breast cancer
- Discontinued Gastric cancer; Non-small cell lung cancer; Prostate cancer
Most Recent Events
- 15 Jan 2025 The West German Study Group, in collaboration with Roche completes a phase-II clinical trial in Breast cancer (Combination therapy, Neoadjuvant therapy) in Germany (IV) (NCT01817452)
- 28 Nov 2024 Roche completes phase III APHINITY trial in Breast cancer (Adjuvant therapy, Combination therapy, Early-stage disease) at multiple countries worldwide (NCT01358877)
- 13 Sep 2024 Efficacy data from the phase II trial in Breast cancer presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)