Drug Profile


Alternative Names: GC-1008

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Cambridge Antibody Technology
  • Developer Baylor College of Medicine; Genzyme Corporation; Sanofi Genzyme
  • Class Anti-inflammatories; Monoclonal antibodies
  • Mechanism of Action Transforming growth factor beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Focal segmental glomerulosclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Osteogenesis imperfecta
  • No development reported Fibrosis; Malignant melanoma; Pulmonary fibrosis; Renal cancer
  • Discontinued Focal segmental glomerulosclerosis

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 15 Jul 2017 Phase-I clinical trials in Osteogenesis imperfecta in USA (IV) (NCT03064074)
  • 27 Feb 2017 Baylor College of Medicine in collaboration with Genzyme plans a phase I trial for Osteogenesis imperfecta in USA (NCT03064074)
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