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Pimavanserin - ACADIA Pharmaceuticals

Drug Profile

Pimavanserin - ACADIA Pharmaceuticals

Alternative Names: ACP-103; BVF-048; Nuplazid; Pimavanserin tartrate

Latest Information Update: 15 Mar 2024

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At a glance

  • Originator ACADIA Pharmaceuticals
  • Class Amides; Antidepressants; Antiparkinsonians; Antipsychotics; Behavioural disorder therapies; Fluorinated hydrocarbons; Piperidines; Sleep disorder therapies; Small molecules
  • Mechanism of Action Serotonin 2A receptor antagonists; Serotonin 2A receptor inverse agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Psychotic disorders
  • Phase III Major depressive disorder; Schizophrenia
  • Phase II/III Behavioural disorders
  • Phase II Agitation; Insomnia
  • No development reported Psychiatric disorders
  • Discontinued Drug-induced akathisia; Drug-induced dyskinesia

Most Recent Events

  • 11 Mar 2024 Efficacy and adverse events data from a phase III ADVANCE-2 trial in Schizophrenia released by Acadia Pharmaceuticals
  • 13 Dec 2023 US District Court for the District of Delaware granted summary judgment to Acadia Pharmaceuticals against MSN Laboratories, MSN Pharmaceuticals and other ANDA filers, confirming the validity of the NUPLAZID® '740 composition of matter patent in USA
  • 18 Sep 2023 ACADIA Pharmaceuticals updated the box warning for Pimavanserin
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