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Ambrisentan - Gilead Sciences/GSK

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Drug Profile

Ambrisentan - Gilead Sciences/GSK

Alternative Names: BSF 208075; GSK 1325760; GSK1325760A; Letairis; Volibris

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Knoll
  • Developer Gilead Sciences; GSK
  • Class Antihypertensives; Phenylpropionates; Pyridazines; Small molecules
  • Mechanism of Action Endothelin A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension; Pulmonary hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pulmonary arterial hypertension
  • Discontinued Idiopathic pulmonary fibrosis; Pulmonary hypertension

Most Recent Events

  • 17 Dec 2019 GlaxoSmithKline completes a phase I trial in Hypertension (In volunteers) in United Kingdom (NCT04095286)
  • 30 Sep 2019 GlaxoSmithKline initiates a phase I trial for Pulmonary arterial hypertension (In volunteers) in the United Kingdom (PO, Tablet) (NCT04095286)
  • 19 Sep 2019 GlaxoSmithKline plans a phase I trial in healthy volunteers (PO) (NCT04095286)

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