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Crenolanib - AROG Pharmaceuticals/Pfizer

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Drug Profile

Crenolanib - AROG Pharmaceuticals/Pfizer

Alternative Names: ARO-002; ARO-002-26; CP-868,596; CP-868,596-26; Crenolanib besylate - AROG Pharmaceuticals/Pfizer; IND-112201

Latest Information Update: 31 Jan 2025

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At a glance

  • Originator Pfizer
  • Developer AROG Pharmaceuticals
  • Class Amines; Antineoplastics; Benzimidazoles; Piperidines; Quinolines; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Platelet-derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Gastric cancer; Soft tissue sarcoma; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Gastrointestinal stromal tumours
  • Phase II Glioblastoma
  • No development reported Gastric cancer; Glioma; Oesophageal cancer
  • Discontinued Non-small cell lung cancer; Soft tissue sarcoma; Systemic mastocytosis

Most Recent Events

  • 07 Dec 2024 Adverse events and efficacy data from the phase II trial in Acute myeloid leukemia presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 02 Jul 2024 Chemical structure information added
  • 18 Dec 2023 AROG Pharmaceuticals completes a phase II trial in Acute myeloid leukaemia in USA (NCT02400255)

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