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Metreleptin - Amryt Pharma

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Drug Profile

Metreleptin - Amryt Pharma

Alternative Names: Human recombinant methionyl leptin; Methionyl human leptin; Myalept; MYALEPTA; r-metHuLeptin; Recombinant methionyl human leptin

Latest Information Update: 24 Jun 2026

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At a glance

  • Originator Amgen
  • Developer Amgen; Amryt Pharma; Beth Israel Deaconess Medical Center; Shionogi; University of Texas Southwestern Medical Center
  • Class Adipokines; Antihyperglycaemics; Obesity therapies; Recombinant proteins
  • Mechanism of Action Leptin receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Lipodystrophy
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Congenital generalised lipodystrophy
  • Phase III Familial partial lipodystrophy
  • Phase II Amenorrhoea
  • No development reported Lipodystrophy; Lipomatosis; Type 1 diabetes mellitus

Most Recent Events

  • 11 May 2026 Amryt Pharma terminated a phase-IIIb trial in Congenital generalised lipodystrophy (In children) in France (Parenteral), (CTIS2022-501781-22-00) (NCT06502990)
  • 28 Mar 2026 No recent reports of development identified for phase-I development in Lipomatosis(In adolescents, In children, In infants, In neonates, In adults) in USA (SC, Injection)
  • 25 Apr 2025 Amryt Pharma initiates a phase-IIIb trial for Congenital generalised lipodystrophy (In children) in France (Parenteral), (CTIS2022-501781-22-00) (NCT06502990)

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