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Dapivirine - Janssen Infectious Diseases BVBA

Drug Profile

Dapivirine - Janssen Infectious Diseases BVBA

Alternative Names: AIDS-105293; Dapivirine ring 004; R-147681; TMC-120

Latest Information Update: 19 Apr 2018

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At a glance

  • Originator Tibotec BVBA
  • Developer International Partnership for Microbicides; Janssen Infectious Diseases BVBA
  • Class Antivirals; Nitriles; Pyrimidines; Small molecules
  • Mechanism of Action Non-nucleoside reverse transcriptase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III HIV infections

Most Recent Events

  • 20 Jul 2018 National Institute of Allergy and Infectious Diseases plans a phase IIa trial for HIV infections (Prevention, Combination therapy, In adolescents, In adults) (NCT03593655)
  • 04 Mar 2018 Efficacy data from the phase IIIb HOPE and DREAM trials in HIV-infections presented at the Annual Meeting of the 25th Conference on Retroviruses and Opportunistic Infections
  • 04 Nov 2017 No recent reports of development identified for phase-I development in HIV-infections(Combination therapy, Prevention) in Belgium (Vaginal, Ring)
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