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Teprotumumab - Horizon Therapeutics

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Drug Profile

Teprotumumab - Horizon Therapeutics

Alternative Names: AMG-632; HZN 001; Insulin-like-growth-factor-1-receptor-antagonist-antibody-River-Vision-Development; R 1507; RG 1507; RO-4858696; RV 001-River-Vision; TEPEZZA; Tepezza; teprotumumab-trbw

Latest Information Update: 23 Feb 2026

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At a glance

  • Originator Genmab; Roche
  • Developer Amgen; Halozyme Therapeutics; Horizon Therapeutics plc; Roche
  • Class Antineoplastics; Eye disorder therapies; Immunotherapies; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action IGF type 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graves ophthalmopathy
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Graves ophthalmopathy
  • Discontinued Advanced breast cancer; Diabetic macular oedema; Diffuse scleroderma; Hodgkin's disease; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Sarcoma; Solid tumours

Most Recent Events

  • 31 Dec 2025 Launched for Graves ophthalmopathy in Brazil, Japan (IV) before December 2025
  • 22 Nov 2025 Amgen completes a phase I trial in Unsepcified (In voulnteers) in China (IV) (NCT07142642)
  • 04 Nov 2025 Amgen completes enrolment in its phase-III trial for phase III trial for Graves ophthalmopathy in Japan (IV, Infusion) (jRCT2031220730)

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