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Ocriplasmin - Oxurion

Drug Profile

Ocriplasmin - Oxurion

Alternative Names: A-01016; Jejetrea®; Jetrea; Microplasmin; Recombinant human microplasmin; Recombinant microplasmin; THR-409

Latest Information Update: 22 Jan 2021

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At a glance

  • Originator University of Leuven
  • Developer Alcon; Oxurion; ThromboGenics; University of Leuven
  • Class Anti-ischaemics; Eye disorder therapies; Peptide fragments; Serine endopeptidases
  • Mechanism of Action Antiplasmin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Retinal disorders; Peripheral arterial occlusive disorders
  • New Molecular Entity Yes
  • Available For Licensing Yes - Thrombosis

Highest Development Phases

  • Marketed Retinal disorders
  • Phase II Diabetic retinopathy
  • Suspended Deep vein thrombosis; Peripheral arterial occlusive disorders; Stroke
  • No development reported Retinal vein occlusion
  • Discontinued Age-related macular degeneration; Diabetic macular oedema

Most Recent Events

  • 05 Jan 2021 ThromboGenics and Wagner Macula and Retina Center terminates the phase II TOTEM trial for Retinal disorders (Vitreomacular traction) in USA (Intravitreous) (NCT04300881)
  • 12 Mar 2020 Ocriplasmin licensed to Inceptua Medicine worldwide for commercialisation
  • 04 Oct 2019 ThromboGenics and Wagner Macula and Retina Center initiates enrolment in the phase II TOTEM trial for Retinal disorders (Vitreomacular traction) in USA (Intravitreous) (NCT04300881)
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