Enzastaurin - Denovo Biopharma

Drug Profile

Enzastaurin - Denovo Biopharma

Alternative Names: DB 102; Enzastaurin hydrochloride; Kinenza; LY-317615

Latest Information Update: 18 Apr 2018

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At a glance

  • Originator Eli Lilly
  • Developer Denovo Biopharma; Eli Lilly
  • Class Antineoplastics; Indoles; Piperidines; Pyridines; Pyrrolidinones; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; Protein kinase C beta inhibitors; Protein-serine-threonine kinase inhibitors; Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diffuse large B cell lymphoma
  • Discontinued Brain cancer; Breast cancer; Cancer; Colorectal cancer; Follicular lymphoma; Glioblastoma; Lung cancer; Lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer; Renal cancer; Solid tumours; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 03 Apr 2018 Denovo Biopharma announced dosing of the first patient in its pivotal phase III ENGINE trial for Diffuse large B cell lymphoma in China and USA (NCT03263026)
  • 20 Mar 2018 Phase-III clinical trials in Diffuse large B cell lymphoma (First-line therapy, Combination therapy) in China and USA (PO) (NCT03263026)
  • 27 Feb 2018 Eli Lilly completes a phase II trial in Non-Hodgkin's lymphoma in USA, Australia, Brazil, India, Mexico and Peru (PO) (NCT00542919)
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