Cediranib - AstraZeneca

Drug Profile

Cediranib - AstraZeneca

Alternative Names: AZD-2171; Cediranib-maleate; Recentin; Zemfirza

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; Cancer Research UK; Institute of Cancer Research; Mario Negri Institute for Pharmacological Research; National Cancer Institute (Canada); National Cancer Institute (USA); Royal Marsden NHS Foundation Trust; University Health Network; University of Manchester; University of Oxford
  • Class Antineoplastics; Quinazolines; Small molecules
  • Mechanism of Action Platelet-derived growth factor inhibitors; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Ovarian cancer
  • Phase II Alveolar soft part sarcoma; Cervical cancer; Endometrial cancer; Mesothelioma; Prostate cancer; Solid tumours
  • Discontinued Acute myeloid leukaemia; Biliary cancer; Breast cancer; Colorectal cancer; Gastric cancer; Gastrointestinal stromal tumours; Glioblastoma; Non-small cell lung cancer; Renal cell carcinoma; Soft tissue sarcoma

Most Recent Events

  • 04 Sep 2018 Phase-II clinical trials in Endometrial cancer (Monotherapy, Second-line therapy or greater, Metastatic disease) in USA (PO) (NCT03660826)
  • 04 Sep 2018 Phase-II clinical trials in Endometrial cancer (Second-line therapy or greater, Metastatic disease, Combination therapy) in USA (PO) (NCT03660826)
  • 29 Jul 2018 Institute of Cancer Research and Royal Marsden NHS Foundation Trust completes the CASPS phase II trial in Alveolar soft part sarcoma (Metastatic disease, In adolescents, In the elderly, In adults) in Australia, Spain, United Kingdom, Italy, Germany, France (PO) (ISRCTN63733470)
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