Drug Profile

Atacicept - Vera Therapeutics

Alternative Names: Anti-Blys/anti-APRIL fusion protein - Vera Therapeutics; BLyS/APRIL-heterotrimers - Vera Therapeutics; TACI-Ig; VT-001

Latest Information Update: 12 Aug 2025

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At a glance

Originator ZymoGenetics
Developer EMD Serono; Merck Serono; Vera Therapeutics; ZymoGenetics
Class Antineoplastics; Antirheumatics; Recombinant fusion proteins; Urologics
Mechanism of Action B cell activating factor inhibitors; Tumour necrosis factor ligand superfamily member 13 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Phase III IgA nephropathy; Lupus nephritis
Phase II/III Systemic lupus erythematosus
Phase II Focal segmental glomerulosclerosis; Lipoid nephrosis; Membranous glomerulonephritis; Nephrotic syndrome
Discontinued Chronic lymphocytic leukaemia; Multiple myeloma; Multiple sclerosis; Non-Hodgkin's lymphoma; Rheumatoid arthritis

07 Jul 2025 Phase-II clinical trials in Focal segmental glomerulosclerosis (In children, In adolescents, In adults, In the elderly, Treatment-experienced) in USA (SC) (NCT06983028)
07 Jul 2025 Phase-II clinical trials in IgA nephropathy (In children, In adolescents, In adults, In the elderly, Treatment-experienced) in USA (SC) (NCT06983028)
07 Jul 2025 Phase-II clinical trials in Lipoid-nephrosis (In children, In adolescents, In adults, In the elderly, Treatment-experienced) in USA (SC) (NCT06983028)

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