Atacicept - Merck Serono

Drug Profile

Atacicept - Merck Serono

Alternative Names: Anti-Blys/anti-APRIL fusion protein; TACI-Ig

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator ZymoGenetics
  • Developer EMD Serono; Merck Serono; ZymoGenetics
  • Class Antirheumatics; Recombinant fusion proteins
  • Mechanism of Action B cell activating factor inhibitors; Tumour necrosis factor ligand superfamily member 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Systemic lupus erythematosus
  • Phase II IgA nephropathy
  • Discontinued Chronic lymphocytic leukaemia; Lupus nephritis; Multiple myeloma; Multiple sclerosis; Non-Hodgkin's lymphoma; Rheumatoid arthritis

Most Recent Events

  • 09 Feb 2018 EMD Serono completes a phase IIb extension trial for Systemic lupus erythematosus in USA, Germany, Belgium, Czech Republic, United Kingdom, Spain, Italy, Bulgaria, Argentina, Brazil, Chile, South Korea, Mexico, Peru, Philippines, Poland, Russia, South Africa (SC) (NCT02070978)
  • 14 Jun 2017 Efficacy, immunogenicity and adverse events data from an extension of the phase IIb Address II trial in Systemic lupus erythematosus presented at the 18th Annual Congress of the European League Against Rheumatism (EULAR-2017)
  • 31 Jan 2017 Phase-II clinical trials in IgA nephropathy in USA (SC) (NCT02808429)
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