Atacicept - Merck Serono

Drug Profile

Atacicept - Merck Serono

Alternative Names: Anti-Blys/anti-APRIL fusion protein; TACI-Ig

Latest Information Update: 16 Nov 2018

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At a glance

  • Originator ZymoGenetics
  • Developer EMD Serono; Merck Serono; ZymoGenetics
  • Class Antirheumatics; Recombinant fusion proteins
  • Mechanism of Action B cell activating factor inhibitors; Tumour necrosis factor ligand superfamily member 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Systemic lupus erythematosus
  • Phase II IgA nephropathy
  • Discontinued Chronic lymphocytic leukaemia; Lupus nephritis; Multiple myeloma; Multiple sclerosis; Non-Hodgkin's lymphoma; Rheumatoid arthritis

Most Recent Events

  • 19 Oct 2018 Pharmacokinetics data from murine models, phase II/III trial (APRIL-SLE) and phase IIb ADDRESS II trial in Systemic lupus erythematosus presented at the 82nd American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting (ACR/ARHP-2018)
  • 19 Oct 2018 Updated efficacy data from a phase IIb ADDRESS II trial in Systemic lupus erythematosus presented at the 82nd American College of Rheumatology and the 52nd Association of Rheumatology Health Professionals Annual Scientific Meeting (ACR/ARHP-2018)
  • 24 Jun 2018 Biomarkers information updated
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