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Atacicept - Vera Therapeutics

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Drug Profile

Atacicept - Vera Therapeutics

Alternative Names: Anti-Blys/anti-APRIL fusion protein - Vera Therapeutics; BLyS/APRIL-heterotrimers - Vera Therapeutics; TACI-Ig; VT-001

Latest Information Update: 11 Jun 2025

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At a glance

  • Originator ZymoGenetics
  • Developer EMD Serono; Merck Serono; Vera Therapeutics; ZymoGenetics
  • Class Antineoplastics; Antirheumatics; Recombinant fusion proteins; Urologics
  • Mechanism of Action B cell activating factor inhibitors; Tumour necrosis factor ligand superfamily member 13 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III IgA nephropathy; Lupus nephritis
  • Phase II/III Systemic lupus erythematosus
  • Discontinued Chronic lymphocytic leukaemia; Multiple myeloma; Multiple sclerosis; Non-Hodgkin's lymphoma; Rheumatoid arthritis

Most Recent Events

  • 02 Jun 2025 Efficacy data from a phase III trial in IgA nephropathy released by Vera Therapeutics
  • 29 May 2025 Vera Therapeutics initiates enrolment in a phase II trial for IgA nephropathy in the US (SC) (NCT07020923)
  • 23 May 2025 Vera Therapeutics withdraws phase III trial due to financial reasons in Lupus nephritis (In adults, In the elderly) in USA, Puerto Rico and Spain (SC) due to business reasons (NCT05609812)

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