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IRX 5183

Drug Profile

IRX 5183

Alternative Names: AGN 195183; IRX5183; NRX 195183; VTP-195183

Latest Information Update: 13 May 2019

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At a glance

  • Originator Allergan
  • Developer Io Therapeutics; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Antineoplastics; Antipsoriatics
  • Mechanism of Action Immunostimulants; Retinoic acid receptor alpha agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Cancer
  • Phase I Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Discontinued Psoriasis; Stem cell mobilisation

Most Recent Events

  • 13 May 2019 Discontinued - Clinical-Phase-Unknown for Psoriasis in USA (PO)
  • 18 Apr 2019 Io Therapeutics terminates a phase I trial in Acute myeloid leukaemia, Myelodysplastic syndromes and Chronic myelomonocytic leukaemia (Second-line therapy or greater) in USA as the study drug supply expired and could not be renewed (PO) (NCT02749708)
  • 14 May 2016 Phase-I/II development for Cancer is ongoing in USA (PO)
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