Drug Profile


Alternative Names: CPT-184; LBQ 707; NVP-LBQ707; ST-1481

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Istituto Nazionale per lo Studio e la Cura dei Tumori; sigma-tau SpA
  • Developer Lees Pharmaceutical Holdings; Novartis; sigma-tau SpA
  • Class Antineoplastics; Benzylisoquinolines; Camptothecins; Heterocyclic compounds with 4 or more rings; Imines; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Discontinued Glioma; Myelodysplastic syndromes; Solid tumours

Most Recent Events

  • 04 Feb 2016 No development reported - Phase-II for Fallopian tube cancer (Recurrent) in China (PO)
  • 04 Feb 2016 No development reported - Phase-II for Ovarian cancer (Recurrent) in China (PO)
  • 04 Feb 2016 No development reported - Phase-II for Peritoneal cancer (Recurrent) in China (PO)
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