Drug Profile
Paclitaxel - Beigene/Celgene Corporation
Alternative Names: ABI-007; ABRAXANE; Abraxane; ABRAXUS; Albumin-bound paclitaxel - Celgene Corporation; Coraxane; Coroxane; Nab-Paclitaxel; Systemic nanoparticle albumin-bound paclitaxelLatest Information Update: 08 Mar 2024
Price :
$50
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At a glance
- Originator Abraxis BioScience
- Developer Abraxis BioScience; AstraZeneca; Australian and New Zealand Urogenital and Prostate Cancer Group; BeiGene; Big Ten Cancer Research Consortium; Biotoscana; Cambridge University Hospitals; Cancer Research UK; Celgene Corporation; Columbia University; Eli Lilly and Company; Emory University; Fondazione Sandro Pitigliani; Genentech; Institut fuer Frauengesundheit; M. D. Anderson Cancer Center; Merck Sharp & Dohme; National Cancer Institute (USA); NCIC Clinical Trials Group; New York University School of Medicine; Oncosur; PrECOG; Southeastern Gynecologic Oncology; Taiho Pharmaceutical; University of California, Davis; University of Iowa; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
- Class Antineoplastics; Diterpenes; Paclitaxels; Skin disorder therapies; Small molecules; Taxanes; Vascular disorder therapies
- Mechanism of Action Angiogenesis inhibitors; Mitosis inhibitors; Platelet-derived growth factor inhibitors; Proto-oncogene protein c-bcl-2 inhibitors; Tubulin inhibitors; Tubulin polymerisation promoters
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Marketed Breast cancer; Gastric cancer; Non-small cell lung cancer; Pancreatic cancer
- Registered Squamous cell cancer
- Phase II Biliary cancer; Cholangiocarcinoma; Colorectal cancer; Head and neck cancer; HER2 negative breast cancer; Malignant melanoma; Oesophageal cancer; Small cell lung cancer; Urogenital cancer
- Phase I/II Multiple myeloma; Solid tumours
- No development reported Bladder cancer; Ovarian cancer; Prostate cancer
- Discontinued Coronary artery restenosis; Peripheral arterial disorders; Vascular restenosis
Most Recent Events
- 18 Jan 2024 Efficacy and adverse event data from the phase II ALPACA trial in Pancreatic cancer presented at the 2024 Gastrointestinal Cancers Symposium (ASCO-GCS-2024)
- 15 Dec 2023 ORIC Pharmaceuticals terminates a phase I trial for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA (PO) due to IND withdrawal (NCT03928314)
- 17 Aug 2023 Celgene completes the phase II abound2L+ trial in Non-small cell lung cancer (Late-stage disease, Second-line therapy or greater, Combination therapy, Monotherapy) in USA, Spain, Canada, France, Germany, Italy, and United Kingdom (IV) (NCT02250326) (EudraCT2014-001105-41)