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Paclitaxel - Beigene/Celgene Corporation

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Drug Profile

Paclitaxel - Beigene/Celgene Corporation

Alternative Names: ABI-007; ABRAXANE; Abraxane; ABRAXUS; Albumin-bound paclitaxel - Celgene Corporation; Coraxane; Coroxane; Nab-Paclitaxel; Systemic nanoparticle albumin-bound paclitaxel

Latest Information Update: 08 Mar 2024

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At a glance

  • Originator Abraxis BioScience
  • Developer Abraxis BioScience; AstraZeneca; Australian and New Zealand Urogenital and Prostate Cancer Group; BeiGene; Big Ten Cancer Research Consortium; Biotoscana; Cambridge University Hospitals; Cancer Research UK; Celgene Corporation; Columbia University; Eli Lilly and Company; Emory University; Fondazione Sandro Pitigliani; Genentech; Institut fuer Frauengesundheit; M. D. Anderson Cancer Center; Merck Sharp & Dohme; National Cancer Institute (USA); NCIC Clinical Trials Group; New York University School of Medicine; Oncosur; PrECOG; Southeastern Gynecologic Oncology; Taiho Pharmaceutical; University of California, Davis; University of Iowa; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine
  • Class Antineoplastics; Diterpenes; Paclitaxels; Skin disorder therapies; Small molecules; Taxanes; Vascular disorder therapies
  • Mechanism of Action Angiogenesis inhibitors; Mitosis inhibitors; Platelet-derived growth factor inhibitors; Proto-oncogene protein c-bcl-2 inhibitors; Tubulin inhibitors; Tubulin polymerisation promoters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma; Pancreatic cancer
  • New Molecular Entity No

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer; Non-small cell lung cancer; Pancreatic cancer
  • Registered Squamous cell cancer
  • Phase II Biliary cancer; Cholangiocarcinoma; Colorectal cancer; Head and neck cancer; HER2 negative breast cancer; Malignant melanoma; Oesophageal cancer; Small cell lung cancer; Urogenital cancer
  • Phase I/II Multiple myeloma; Solid tumours
  • No development reported Bladder cancer; Ovarian cancer; Prostate cancer
  • Discontinued Coronary artery restenosis; Peripheral arterial disorders; Vascular restenosis

Most Recent Events

  • 18 Jan 2024 Efficacy and adverse event data from the phase II ALPACA trial in Pancreatic cancer presented at the 2024 Gastrointestinal Cancers Symposium (ASCO-GCS-2024)
  • 15 Dec 2023 ORIC Pharmaceuticals terminates a phase I trial for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA (PO) due to IND withdrawal (NCT03928314)
  • 17 Aug 2023 Celgene completes the phase II abound2L+ trial in Non-small cell lung cancer (Late-stage disease, Second-line therapy or greater, Combination therapy, Monotherapy) in USA, Spain, Canada, France, Germany, Italy, and United Kingdom (IV) (NCT02250326) (EudraCT2014-001105-41)
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