Palovarotene - Clementia Pharmaceuticals

Drug Profile

Palovarotene - Clementia Pharmaceuticals

Alternative Names: Clm-001; R-667; RAR-gamma; RG-667; RO-3300074

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Roche
  • Developer Clementia Pharmaceuticals; Roche
  • Class Benzoic acids; Eye disorder therapies; Naphthalenes; Pyrazoles; Small molecules
  • Mechanism of Action Retinoic acid receptor gamma agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fibrodysplasia ossificans progressiva; Bone disorders
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Fibrodysplasia ossificans progressiva
  • Phase II Bone disorders
  • Phase I Dry eyes
  • Discontinued Emphysema

Most Recent Events

  • 23 Oct 2018 Clementia Pharmaceuticals announces intention to submit NDA to US FDA for Fibrodysplasia ossificans progressiva in second half of 2019
  • 02 Oct 2018 Phase-I clinical trials in Dry eyes (In volunteers) (Ophthalmic)
  • 02 Oct 2018 Clementia Pharmaceuticals plans a phase I proof of concept trial for Dry eyes (Ophthalmic), in 2019
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