Palovarotene - Clementia Pharmaceuticals

Drug Profile

Palovarotene - Clementia Pharmaceuticals

Alternative Names: Clm-001; R-667; RAR-gamma; RG-667; RO-3300074

Latest Information Update: 02 Apr 2018

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At a glance

  • Originator Roche
  • Developer Clementia Pharmaceuticals; Roche
  • Class Benzoic acids; Naphthalenes; Pyrazoles; Small molecules
  • Mechanism of Action Retinoic acid receptor gamma agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fibrodysplasia ossificans progressiva
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Fibrodysplasia ossificans progressiva
  • Phase II Bone disorders
  • Discontinued Emphysema

Most Recent Events

  • 01 Mar 2018 Phase-II clinical trials in Bone disorders (In infants, In children, In adolescents) in USA (unspecified route) (NCT03442985)
  • 28 Feb 2018 Clementia Pharmaceuticals plans the phase II MO-Ped trial in Bone disorders (In adolescents, In children, In infants) in Q1 2018
  • 01 Dec 2017 Clementia initiates enrolment in the phase III MOVE trial in Fibrodysplasia ossificans progressiva (In children, In adolescents, In adults) in USA (PO)
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