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Omacetaxine mepesuccinate - Teva Pharmaceutical Industries

Drug Profile

Omacetaxine mepesuccinate - Teva Pharmaceutical Industries

Alternative Names: C41443; Ceflatonin®; CGX-635; CXS-635; HHT; Homoharringtonine; Homoharringtonine-ChemGenex; NCI 141633; Omapro™; Synribo

Latest Information Update: 02 Oct 2021

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At a glance

  • Originator ChemGenex Pharmaceuticals; Stragen Pharma SA
  • Developer ChemGenex Pharmaceuticals; Roswell Park Cancer Institute; Teva Pharmaceutical Industries; University of Hong Kong; University of Texas M. D. Anderson Cancer Center
  • Class Alkaloids; Antineoplastics; Harringtonines; Small molecules
  • Mechanism of Action Apoptosis stimulants; Cyclin D1 inhibitors; MCL1 protein inhibitors; Protein synthesis inhibitors; Proto oncogene protein c-myc inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Chronic myeloid leukaemia; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic myeloid leukaemia
  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes
  • No development reported Haematological malignancies
  • Discontinued Acute promyelocytic leukaemia; Solid tumours

Most Recent Events

  • 21 Feb 2021 Omacetaxine mepesuccinate is still in phase II trials for Acute myeloid leukaemia in Hong Kong (NCT03135054) (NDR batch 18)
  • 10 Dec 2020 University of Hong Kong completes enrolment in a phase II trial in Acute myeloid leukaemia (Newly diagnosed, Second-line therapy or greater, Combination therapy) in HongKong (NCT03135054)
  • 14 Apr 2020 M.D. Anderson Cancer Center and Teva Pharmaceuticals completes the phase II trial in myelodysplastic syndrome in USA (SC) (NCT02159872)
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