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Drug Profile


Alternative Names: Glionix; Lucanix; Ranagengliotucel-T; TGF-beta2 antisense gene modified allogeneic tumour cell vaccine - NovaRx

Latest Information Update: 19 Aug 2016

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At a glance

  • Originator Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Developer NovaRx Corporation
  • Class Antisense DNA; Cancer vaccines; DNA vaccines; Tumour cell vaccines
  • Mechanism of Action Immunostimulants; Transforming growth factor beta inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Discontinued Glioma; Non-small cell lung cancer

Most Recent Events

  • 19 Aug 2016 NovaRx intends to initiate new clinical studies for Belagenpumatucel-L, either as monotherapy or combination therapy
  • 28 Sep 2013 Efficacy data from a phase III trial in Non-small cell lung cancer presented at the European Cancer Congress 2013 (ECC-2013)
  • 25 Jul 2013 Discontinued - Phase-I for Glioma in USA (SC) prior to July 2013
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