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Axitinib - Pfizer

Drug Profile

Axitinib - Pfizer

Alternative Names: AG-013736; AG-13,736; Inlyta

Latest Information Update: 11 Apr 2020

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At a glance

  • Originator Pfizer
  • Developer Grupo Espanol de Tumores Neuroendocrinos; H. Lee Moffitt Cancer Center and Research Institute; Merck Sharp & Dohme; Netherlands Cancer Institute; Pfizer; Royal Marsden Hospital; SCRI Development Innovations; SFJ Pharmaceuticals; Sheffield Teaching Hospitals NHS Foundation Trust; University of Cincinnati; University of Texas M. D. Anderson Cancer Center; University of Wisconsin-Madison
  • Class Antineoplastics; Eye disorder therapies; Imidazoles; Indazoles; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma
  • Phase II/III Neuroendocrine tumours
  • Phase II Carcinoid tumour; Colorectal cancer; Glioblastoma; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Prostate cancer; Soft tissue sarcoma; Urogenital cancer
  • No development reported Solid tumours
  • Discontinued Breast cancer; Gastric cancer; Gastrointestinal cancer; Pancreatic cancer; Thyroid cancer

Most Recent Events

  • 23 Jan 2020 Registered for Renal cell carcinoma (Combination therapy, First-line therapy, Late-stage disease, Metastatic disease, Recurrent) in Canada (PO)
  • 25 Oct 2019 Pfizer completes the phase I VEGF Liver 100 trial in Liver cancer (Late-stage disease, Metastatic disease, Combination therapy, First-line therapy) in Japan (PO) (NCT03289533)
  • 05 Sep 2019 Pfizer completes a phase Ib trial for Solid tumours (Combination therapy, Late stage disease) in USA (NCT01999972)
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