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Radium-223 chloride - Bayer HealthCare

Drug Profile

Radium-223 chloride - Bayer HealthCare

Alternative Names: AC1O4D1M; Alpharadin; ATI-BC-1; BAY88-8223; Radium Ra 233 dichloride; Radium-223; Radium-223 dichloride; Xofigo

Latest Information Update: 17 Sep 2019

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At a glance

  • Originator Algeta
  • Developer Algeta; Bayer HealthCare; Janssen; Medica Scientia Innovation Research; Royal Marsden NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; The Institute of Cancer Research; Thomas Jefferson University; University of Texas M. D. Anderson Cancer Center; University of Utah
  • Class Analgesics; Antineoplastics; Radiopharmaceuticals; Small molecules
  • Mechanism of Action Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Bone metastases
  • Phase III Prostate cancer
  • Phase I/II Multiple myeloma
  • No development reported Osteosarcoma
  • Discontinued Cancer pain

Most Recent Events

  • 13 Aug 2019 Bayer completes a phase II clinical trial in Bone metastases (HER2 negative hormone receptor positive breast cancer) in Israel, Spain, Austria, Denmark, Finland, United Kingdom, Czech Republic, Netherlands, Sweden, Poland, Ireland, France, Germany, USA, Canada, Hong Kong, Israel, South Korea, Norway, Singapore, Switzerland and Taiwan (IV) (NCT02258464) (EudraCT2014-002113-39)
  • 26 Jun 2019 Bayer plans a phase I/II trial for Non-small cell lung cancer (Combination therapy, Late-stage disease) in Belgium and Germany in October 2019 (NCT03996473)
  • 19 Apr 2019 Bayer initiates enrolment in the phase III DORA trial for Prostate cancer (Combination therapy, Hormone refractory, Metastatic disease) in USA (IV) (NCT03574571)
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