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Mavorixafor - X4 Pharmaceuticals

Drug Profile

Mavorixafor - X4 Pharmaceuticals

Alternative Names: ABSK-081; AMD-070; AMD-11070; X4P 001 RD; X4P-001; X4P-001-IO; XOLREMDI

Latest Information Update: 04 Jul 2024

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At a glance

  • Originator AnorMED
  • Developer Abbisko Therapeutics; X4 Pharmaceuticals
  • Class Antineoplastics; Antiretrovirals; Benzimidazoles; Diamines; Hydroquinones; Small molecules
  • Mechanism of Action CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - WHIM syndrome; Waldenstrom's macroglobulinaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Registered WHIM syndrome
  • Phase III Neutropenia
  • Phase I/II Triple negative breast cancer
  • Discontinued HIV-1 infections; Malignant melanoma; Renal cell carcinoma; Solid tumours; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 27 Jun 2024 Phase-III clinical trials in Neutropenia (In adolescents, In adults, In the elderly) in Georgia (PO) (NCT06056297)
  • 27 Jun 2024 Adverse events and efficacay data from a phase I/II trial in Chronic neutropenia released by X4 Pharmaceuticals
  • 07 May 2024 X4 Pharmaceuticals announces intention to submit regulatory application to European Medicines Agency (EMA) for WHIM syndrome in late 2024 or early 2025
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