Oportuzumab monatox - Eleven Biotherapeutics

Drug Profile

Oportuzumab monatox - Eleven Biotherapeutics

Alternative Names: Anti-ECAM exotoxin A fusion protein; Proxinium; VB-4847; VB-845; VB4-845; Vicinium

Latest Information Update: 09 Apr 2018

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At a glance

  • Originator University of Zurich
  • Developer Eleven Biotherapeutics; National Cancer Institute (USA); Viventia Biotechnologies
  • Class Antineoplastics; Drug conjugates; Immunotoxins; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action Protein synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Head and neck cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Bladder cancer
  • Phase II/III Head and neck cancer
  • No development reported Liver cancer; Ovarian cancer

Most Recent Events

  • 03 Apr 2018 Preliminary adverse events data from the phase III VISTA trial in Bladder cancer released by Eleven Therapeutics
  • 12 Mar 2018 Eleven Therapeutics completes enrolment in the phase III VISTA trial in Bladder cancer
  • 20 Nov 2017 Oportuzumab monatox - Eleven Biotherapeutics is available for licensing as of 20 Nov 2017. http://www.elevenbio.com
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