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Iclaprim - Motif Bio

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Drug Profile

Iclaprim - Motif Bio

Alternative Names: AR-100; MTF-100; Ro-48-2622

Latest Information Update: 28 Aug 2023

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At a glance

  • Originator Roche
  • Developer Arpida; Evolva Holding SA; Motif Bio; Otto von Guericke University Magdeburg
  • Class Amines; Anti-infectives; Antibacterials; Antiprotozoals; Pyrimidines; Small molecules
  • Mechanism of Action Tetrahydrofolate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Methicillin-resistant Staphylococcus aureus infections
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preregistration Skin and soft tissue infections
  • Phase II Nosocomial pneumonia; Ventilator associated pneumonia
  • No development reported Methicillin-resistant Staphylococcus aureus infections; Nosocomial infections; Staphylococcal infections; Toxoplasmosis
  • Discontinued Chlamydial infections; Gonorrhoea

Most Recent Events

  • 28 Aug 2023 No recent reports of development identified for preclinical development in Staphylococcal-infections(In children) in United Kingdom
  • 28 Jun 2023 No recent reports of development identified for preclinical development in Toxoplasmosis in United Kingdom
  • 28 Aug 2022 No recent reports of development identified for preclinical development in Methicillin-resistant-Staphylococcus-aureus-infections in United Kingdom (IV, Infusion)

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