Drug Profile

Baricitinib - Eli Lilly and Company/Incyte Corporation

Alternative Names: INCB 028050; INCB 28050; LY 3009104; Olumiant

Latest Information Update: 17 Mar 2025

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At a glance

Originator Incyte Corporation
Developer Eli Lilly; Eli Lilly and Company; Incyte Corporation; Natco Pharma
Class Acetonitriles; Anti-inflammatories; Antipsoriatics; Antirheumatics; Azetidines; Eye disorder therapies; Pyrazoles; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules
Mechanism of Action Janus kinase 1 inhibitors; Janus kinase 2 inhibitors; TYK2 kinase inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Systemic lupus erythematosus
New Molecular Entity Yes

Marketed Alopecia areata; Atopic dermatitis; Rheumatoid arthritis
Registered COVID 2019 infections
Phase III Juvenile rheumatoid arthritis; Uveitis
Phase II/III Aicardi-Goutieres syndrome; Hereditary autoinflammatory diseases
Discontinued Diabetic nephropathies; Primary biliary cirrhosis; Psoriasis; Psoriatic arthritis; Systemic lupus erythematosus

08 Mar 2025 The efficacy and adverse event data from a phase III BRAVE-AA-PEDS trial in Alopecia areata released by Eli Lilly and Company
29 Jan 2025 Eli Lilly and Company completes the phase-II/III BRAVE-AA1 trial in Alopecia areata in the US, Japan, South Korea, Mexico, and Puerto Rico (NCT03570749)
28 Jan 2025 Eli Lilly and Company terminates phase II/III clinical trials in Aicardi-Goutieres-syndrome (In infants, In children, In adolescents, In adults, In the elderly) in Japan due to efficacy/effectiveness reasons (Tablet, Suspension) (NCT04517253)

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