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Alternative Names:
Pashireochidopamo salt; pasireotide LAR; Pasireotide pamoate; SIGNIFOR; SIGNIFOR LAR; SOM 230; SOM 230 LAR; SOM230C
Latest Information Update: 13 Mar 2023
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At a glance
Originator
Novartis
Developer
H. Lee Moffitt Cancer Center and Research Institute; Novartis; UNC Lineberger Comprehensive Cancer Center; University of Arkansas for Medical Sciences; University of Miami
Class
Analgesics; Antineoplastics; Antisecretories; Cyclic peptides; Macrocyclic compounds; Oligopeptides; Peptidomimetics
Mechanism of Action
Corticotropin releasing hormone inhibitors; Growth hormone-releasing hormone inhibitors; Insulin-like growth factor I inhibitors; Vascular endothelial growth factor A inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
02 Mar 2023
H. Lee Moffitt Cancer Center and Research Institute in collaboration with Novartis and Recordati complete a phase II trial for Neuroendocrine tumours (Metastatic disease; Inoperable/Unresectable) in the US (IM) (NCT01253161)
27 Apr 2022
No development reported - Phase-II for Pituitary ACTH Hypersecretion (Monotherapy; Combination therapy) in Australia, Belgium, Brazil, Bulgaria, Colombia, Greece, Germany, Hungary, India, Italy, Malaysia, Mexico, Spain (SC)
04 Jun 2021
Long-term efficacy and adverse event data from the phase II LUNA trial in Neuroendocrine carcinoma presented at the 57th Annual Meeting of the American Society of Clinical Oncology (ASCO-2021)
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