Pasireotide - Novartis

Drug Profile

Pasireotide - Novartis

Alternative Names: pasireotide-LAR; Signifor; Signifor LAR; SOM-230; SOM-230-LAR; SOM230C

Latest Information Update: 31 May 2018

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At a glance

  • Originator Novartis
  • Developer H. Lee Moffitt Cancer Center and Research Institute; Novartis; UNC Lineberger Comprehensive Cancer Center; University of Arkansas for Medical Sciences; University of Miami
  • Class Antineoplastics; Cyclic peptides; Macrocyclic compounds; Oligopeptides; Peptidomimetics
  • Mechanism of Action Corticotropin-releasing-hormone-Inhibitors; Growth hormone-releasing hormone inhibitors; Insulin-like growth factor I inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acromegaly; Pituitary ACTH hypersecretion; Neuroendocrine tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pituitary ACTH hypersecretion
  • Registered Acromegaly; Gigantism
  • Phase III Pancreatic disorders
  • Phase II Cluster headache; Gastrointestinal disorders; Hepatocellular carcinoma; Meningioma; Neuroendocrine tumours; Pituitary cancer; Prostate cancer; Uveal melanoma
  • No development reported Gastrointestinal cancer; Malignant melanoma; Merkel cell carcinoma; Pancreatic cancer; Radiation injuries
  • Discontinued Carcinoid tumour

Most Recent Events

  • 19 Apr 2018 Registered for Pituitary ACTH Hypersecretion in Japan in first quarter of 2018 (IM)
  • 17 Mar 2018 Efficacy data from an exploratory analysis of a phase III trial in Pituitary ACTH Hypersecretion presented at the 100th Annual Meeting of the Endocrine Society (ENDO-2018)
  • 26 Jan 2018 Novartis withdraws phase II trial in Pituitary ACTH Hypersecretion in USA prior to enrolment, due to stringent inclusion/exclusion criteria (NCT02780882)
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