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HuMax IL8 - Bristol-Myers Squibb/Genmab

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Drug Profile

HuMax IL8 - Bristol-Myers Squibb/Genmab

Alternative Names: anti-IL8 mAb - Bristol-Myers Squibb/Genmab; BMS-986253; HuMax-IL8; HuMax-Inflam; HuMax®-IL8; MDX 018

Latest Information Update: 20 Jun 2024

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At a glance

  • Originator Genmab; Medarex
  • Developer Bristol-Myers Squibb; Columbia University; Genmab; Icahn School of Medicine at Mount Sinai; Medarex; NYU Langone Health; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Anti-inflammatories; Antineoplastics; Immunotherapies; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 8 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II COVID 2019 infections; Liver cancer; Non-small cell lung cancer; Squamous cell cancer
  • Phase I/II Prostate cancer; Solid tumours
  • Discontinued Autoimmune disorders; Glioblastoma; Palmoplantar pustulosis

Most Recent Events

  • 06 Jun 2024 Bristol-Myers Squibb reinitiates enrollment in a phase I trial for Solid tumours (Combination therapy, Late stage disease, Metastatic disease, Inoperable/Unresectable) in USA (IV) (NCT04572451)
  • 23 May 2024 Bristol-Myers Squibb suspends a phase I trial for Solid tumours (Combination therapy; Late stage disease, Metastatic disease, Inoperable/unresectable) in USA (IV) (NCT04572451)
  • 16 Nov 2023 Bristol-Myers Squibb in collaboration with Icahn School of Medicine at Mount Sinai completes a phase II trial in Liver cancer and Non-small Cell Lung Cancer (Combination therapy, Neoadjuvant therapy) in USA (PO) (NCT04123379)

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