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HuMax IL8 - Bristol-Myers Squibb/Genmab

Drug Profile

HuMax IL8 - Bristol-Myers Squibb/Genmab

Alternative Names: anti-IL8 mAb - Bristol-Myers Squibb/Genmab; BMS-986253; HuMax-IL8; HuMax-Inflam; HuMax®-IL8; MDX 018

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Genmab; Medarex
  • Developer Bristol-Myers Squibb; Columbia University; Genmab; Icahn School of Medicine at Mount Sinai; Medarex; NYU Langone Health; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Anti-inflammatories; Antineoplastics; Immunotherapies; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 8 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II COVID 2019 infections; Liver cancer; Non-small cell lung cancer; Squamous cell cancer
  • Phase I/II Prostate cancer; Solid tumours
  • Discontinued Autoimmune disorders; Glioblastoma; Palmoplantar pustulosis

Most Recent Events

  • 01 Jul 2022 National Cancer Institute plans a phase I/II trial for Myelodysplastic syndromes (Monotherapy, Combination therapy) in USA (IV, Infusion) in July 2022 (NCT05148234)
  • 03 Jun 2022 Interim efficacy and adverse events data from a phase Ib/II MAGIC-8 trial in prostate cancer presented at the 58th Annual Meeting of the American Society of Clinical Oncology (ASCO-2022)
  • 07 Dec 2021 Columbia University and Bristol-Myers Squibb terminates a phase-II trials in COVID-2019 infections in cancer patients (Treatment-experienced) in USA (IV) (NCT04347226)
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