Drug Profile

Eltrombopag - Novartis

Alternative Names: 497115; Eltrombopag olamine; ETB-115; Promacta; Reboredo; Revolade; SB-497115; SB-497115-GR

Latest Information Update: 02 Jul 2026

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At a glance

Originator Ligand Pharmaceuticals
Developer French Innovative Leukemia Organisation; GlaxoSmithKline; Groupe Francophone des Myelodysplasies; GSK; Novartis; Technische Universitat Dresden
Class Antianaemics; Antineoplastics; Benzoates; Biphenyl compounds; Carboxylic acids; Hydrazines; Pyrazoles; Radioprotectives; Small molecules
Mechanism of Action Thrombopoietin receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Aplastic anaemia; Idiopathic thrombocytopenic purpura
New Molecular Entity Yes

Marketed Aplastic anaemia; Idiopathic thrombocytopenic purpura; Thrombocytopenia
Phase III Acute radiation syndrome
Phase II Acute myeloid leukaemia; Myelodysplastic syndromes; Transplant rejection
Phase I/II Chronic myelomonocytic leukaemia

25 Jun 2026 Novartis Pharmaceuticals plans phase II VAYHIT-P trial in Thrombocytopenia (Combination therapy, Late-stage disease, In children) in February 2027 (PO) (NCT07660172)
27 Jan 2025 Novartis completes phase II ESCALATE trial in Aplastic anaemia (Combination therapy, In adolescents, In children, In infants, Treatment-experienced, Treatment naive) in USA, Hong Kong, Netherlands, Portugal, Russia, Thailand, United Kingdom (PO) (NCT03025698) (EudraCT2015-003166-91)
06 Dec 2024 Novartis Pharmaceuticals completes Phase-II clinical trials in Aplastic anaemia (In children, In adolescents, In adults, In the elderly, Combination therapy, Treatment-naive) in China, Japan, South Korea and Taiwan (PO) (NCT04328727)

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