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Eltrombopag - Novartis

Drug Profile

Eltrombopag - Novartis

Alternative Names: 497115; Eltrombopag olamine; ETB-115; Promacta; Reboredo; Revolade; SB-497115; SB-497115-GR

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Ligand Pharmaceuticals
  • Developer French Innovative Leukemia Organisation; GlaxoSmithKline; Groupe Francophone des Myelodysplasies; GSK; Novartis; Technische Universitat Dresden
  • Class Antianaemics; Antineoplastics; Benzoates; Biphenyl compounds; Carboxylic acids; Hydrazines; Pyrazoles; Radioprotectives; Small molecules
  • Mechanism of Action Thrombopoietin receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Aplastic anaemia; Idiopathic thrombocytopenic purpura
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Aplastic anaemia; Idiopathic thrombocytopenic purpura; Thrombocytopenia
  • Phase III Acute radiation syndrome
  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes; Transplant rejection
  • Phase I/II Chronic myelomonocytic leukaemia

Most Recent Events

  • 22 Sep 2023 Novartis Pharmaceuticals completes the phase II trial in Idiopathic thrombocytopenic purpura (Newly diagnosed, Combination therapy) in Germany (PO) (NCT04346654)
  • 17 May 2023 Novartis completes a phase II trial in Aplastic anaemia in China (PO) (NCT03988608)
  • 10 Dec 2022 Adverse events, efficacy and pharmacokinetics data from the phase II ESCALATE trial in Aplastic anaemia presented at the 64th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2022)
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