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Capivasertib - AstraZeneca

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Drug Profile

Capivasertib - AstraZeneca

Alternative Names: AZD 5363; Truqap

Latest Information Update: 04 Aug 2025

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At a glance

  • Originator Astex Therapeutics; Cancer Research Technology; The Institute of Cancer Research
  • Developer AstraZeneca
  • Class Antineoplastics; Piperidines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Proto-oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed HER2 negative breast cancer
  • Phase III Prostate cancer; Triple negative breast cancer
  • Phase II Breast cancer; Endometrial cancer; Gastric cancer; Meningioma; Non-Hodgkin's lymphoma
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Preclinical Diffuse large B cell lymphoma
  • Discontinued Non-small cell lung cancer

Most Recent Events

  • 28 Jul 2025 AstraZeneca plans a phase I pharmacokinetic trial (In volunteers) in USA (PO), in July 2025 (NCT07088913)
  • 29 Apr 2025 Registered for HER2-negative-breast-cancer (Combination therapy, Late-stage disease, Second-line therapy ad greater, Metastatic disease) in China
  • 29 Apr 2025 Efficacy and adverse event data from a phase III trial in Prostate cancer released by AstraZeneca

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