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Capivasertib - AstraZeneca

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Drug Profile

Capivasertib - AstraZeneca

Alternative Names: AZD 5363; Truqap

Latest Information Update: 10 Mar 2026

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At a glance

  • Originator Astex Therapeutics; Cancer Research Technology; The Institute of Cancer Research
  • Developer AstraZeneca
  • Class Antineoplastics; Piperidines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Proto-oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed HER2 negative breast cancer
  • Phase III Prostate cancer; Triple negative breast cancer
  • Phase II Breast cancer; Endometrial cancer; Gastric cancer; Meningioma; Non-Hodgkin's lymphoma
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • No development reported Diffuse large B cell lymphoma
  • Discontinued Non-small cell lung cancer

Most Recent Events

  • 20 Feb 2026 AstraZeneca and Parexel complete a phase I pharmacokinetic trial in Healthy volunteers in USA (PO) (NCT07088913)
  • 15 Jan 2026 AstraZeneca plans phase I pharmacokinetics trial (In volunteers) in February 2026 (PO) (NCT07343960)
  • 06 Jan 2026 AstraZeneca initiates enrolment in a phase I pharmacokinetics trial (In volunteers) in USA (PO) (NCT07343960)

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