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At a glance
Originator
Astex Therapeutics; Cancer Research Technology; The Institute of Cancer Research
Developer
Astex Therapeutics; AstraZeneca; Cancer Research Technology; Conquer Cancer Foundation; Royal Marsden NHS Foundation Trust; Samsung Medical Center; The Institute of Cancer Research; University of Nottingham; University of Texas M. D. Anderson Cancer Center
Class
Antineoplastics; Piperidines; Pyrimidines; Pyrroles; Small molecules
Mechanism of Action
Proto oncogene protein c-akt inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
No
New Molecular Entity
Yes
Highest Development Phases
Phase III
Breast cancer
Phase II
Gastric cancer; Non-small cell lung cancer; Prostate cancer
18 Jun 2020
National Cancer Institute completes enrolment in a phase II MATCH-Subprotocol Y for Cancer (Late-stage disease) in USA (PO) (NCT04439123)
29 May 2020
Efficacy and adverse events data from the phase I/II ProCAID trial in Prostate cancer presented at the 56th Annual Meeting of the American Society of Clinical Oncology (ASCO-2020)
16 Apr 2020
Phase-III clinical trials in Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in Spain, United Kingdom, USA (PO, Tablet) (NCT04305496) (EudraCT 2019-003629-78)
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