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Capivasertib - AstraZeneca

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Drug Profile

Capivasertib - AstraZeneca

Alternative Names: AZD 5363; Truqap

Latest Information Update: 02 Apr 2024

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At a glance

  • Originator Astex Therapeutics; Cancer Research Technology; The Institute of Cancer Research
  • Developer AstraZeneca
  • Class Antineoplastics; Piperidines; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Registered HER2 negative breast cancer
  • Phase III Prostate cancer; Triple negative breast cancer
  • Phase II Breast cancer; Endometrial cancer; Gastric cancer; Meningioma; Non-Hodgkin's lymphoma
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Preclinical Diffuse large B cell lymphoma
  • Discontinued Non-small cell lung cancer

Most Recent Events

  • 27 Mar 2024 Registered for HER2-negative-breast-cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Recurrent, Second-line therapy or greater) in Japan (PO)
  • 05 Dec 2023 Efficacy and adverse events data from a phase Ib/III CAPItello-292 trial in breast cancer presented at the 46th Annual San Antonio Breast Cancer Symposium (SABCS-2023)
  • 05 Dec 2023 Updated efficacy and adverse events data from a phase III CAPItello-291 trial in Breast cancer presented at the 46th Annual San Antonio Breast Cancer Symposium (SABCS-2023)
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