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Tiomolibdate choline - Monopar Therapeutics

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Drug Profile

Tiomolibdate choline - Monopar Therapeutics

Alternative Names: ALXN-1840; ATN-224; Bis(choline)tetrathiomolybdate; Bis-choline tetrathiomolybdate; Decuprate; WTX-101

Latest Information Update: 26 Nov 2025

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At a glance

  • Originator University of Michigan
  • Developer Alexion AstraZeneca Rare Disease; Attenuon; Cancer Research UK
  • Class Antineoplastics; Heavy metals; Neuroprotectants; Small molecules
  • Mechanism of Action Chelating agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatolenticular degeneration; Amyotrophic lateral sclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hepatolenticular degeneration
  • No development reported Amyotrophic lateral sclerosis
  • Discontinued Breast cancer; Malignant melanoma; Multiple myeloma; Prostate cancer; Solid tumours

Most Recent Events

  • 13 Nov 2025 Monopar Therapeutics announces intention to submit NDA to US FDA for hepatolenticular degeneration in early 2026
  • 20 Oct 2025 Efficacy and adverse-events data from a pooled analysis of phase II WTX101-201, phase II ALXN1840-WD-205, and phase III WTX101- 301 and phase II ALXN1840-WD204 trials in Wilson disease presented at the European Association for the Study of the Liver Congress 2025 (EASL-2025)
  • 23 Sep 2025 Pharmacodynamics data from a phase-II trial in Hepatolenticular degeneration released by Monopar Therapeutics

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