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Tiomolibdate choline - Monopar Therapeutics

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Drug Profile

Tiomolibdate choline - Monopar Therapeutics

Alternative Names: ALXN-1840; ATN-224; Bis(choline)tetrathiomolybdate; Bis-choline tetrathiomolybdate; Decuprate; WTX-101

Latest Information Update: 11 Jun 2026

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At a glance

  • Originator University of Michigan
  • Developer Alexion AstraZeneca Rare Disease; Attenuon; Cancer Research UK; Monopar Therapeutics
  • Class Alcohols; Antineoplastics; Aza compounds; Heavy metals; Neuroprotectants; Quaternary ammonium compounds; Small molecules; Sulfides
  • Mechanism of Action Chelating agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatolenticular degeneration; Amyotrophic lateral sclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hepatolenticular degeneration
  • Discontinued Amyotrophic lateral sclerosis; Breast cancer; Malignant melanoma; Multiple myeloma; Prostate cancer; Solid tumours

Most Recent Events

  • 01 Jun 2026 Efficacy, pharmacodynamics and adverse event data from a phase II trial in Hepatolenticular-degeneration released by Monopar Therapeutics
  • 20 May 2026 Adverse events data from a phase-II trial in Hepatolenticular degeneration released by Monopar Therapeutics
  • 20 Apr 2026 Updated efficacy data from the phase III FoCus trial in Wilson disease released by Monopar Therapeutics

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