Research programme: RNA interference-based therapeutics - RXi Pharmaceuticals

Drug Profile

Research programme: RNA interference-based therapeutics - RXi Pharmaceuticals

Alternative Names: Anti-CTFG RNAi therapy; Anti-VEGF sd-rxRNA; RXI-762; RXI-804; rxRNA®; rxRNAori®; sd-rxRNA®; Self-delivering RNAi compounds - RXi Pharmaceuticals

Latest Information Update: 28 Oct 2018

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At a glance

  • Originator RXi Pharmaceuticals Corporation
  • Developer RXi Pharmaceuticals; RXi Pharmaceuticals Corporation; University of Massachusetts Medical School
  • Class Antineoplastics; Skin disorder therapies; Small interfering RNA; Small molecules
  • Mechanism of Action Connective tissue growth factor inhibitors; Programmed cell death-1 receptor antagonists; RNA interference; TIGIT protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Eye-Disorders; Skin disorders

Highest Development Phases

  • Preclinical Cancer
  • No development reported CNS disorders; Eye-Disorders; Inflammation; Metabolic disorders; Obesity; Respiratory tract disorders; Retinal disorders; Rheumatoid arthritis; Skin disorders
  • Discontinued Cytomegalovirus retinitis

Most Recent Events

  • 28 Oct 2018 No recent reports of development identified for research development in Skin-disorders in USA
  • 02 Aug 2018 RXi Pharmaceuticals has patent protection for sd-rxRNA platform in European Union and Japan
  • 11 May 2018 RXi Pharmaceuticals and Iovance Biotherapeutics agree to co-develop sd-rxRNA® therapeutics and TIL autologous cell therapy for Cancer
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