Recombinant human endostatin - Simcere
Alternative Names: Endostar; Endu; rh-endostatin; YH-16Latest Information Update: 21 Apr 2022
At a glance
- Originator Simcere Pharmaceutical Group
- Developer Peking University; Simcere Pharmaceutical Group
- Class Angiostatic proteins; Antineoplastics; Immunotherapies; Recombinant proteins
- Mechanism of Action Angiogenesis inhibitors; Gelatinase inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Non-small cell lung cancer
- Phase III Malignant pleural effusion
- Phase II/III Colorectal cancer
- Phase II Malignant ascites
- No development reported Brain metastases; Gastric cancer; Malignant melanoma; Oesophageal cancer; Osteosarcoma; Small cell lung cancer
Most Recent Events
- 21 Apr 2022 Phase-III clinical trials in Malignant pleural effusion (Combination therapy) in China (Intrapleural), before April 2022 (Simcere pipeline, April 2022) (NCT04914598)
- 30 Jun 2021 Simcere Pharmaceutical Group plans a phase I trial for Non-small cell lung cancer (Metastatic disease; Late-stage disease, First-line therapy) in the China in July 2021 (IV) (NCT04942301)
- 11 Jun 2021 Phase-II development is ongoing China for Malignant pleural effusion (Intrapleural)