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Doxorubicin liposomal - Celsion Corporation

Drug Profile

Doxorubicin liposomal - Celsion Corporation

Alternative Names: Liposome encapsulated doxorubicin; LTLD; LTSDEL; Lyso-thermosensitive liposomal doxorubicin; ThermoDox

Latest Information Update: 06 Sep 2018

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At a glance

  • Originator Celsion Corporation
  • Developer Brigham and Womens Hospital; Celsion Corporation; Focused Ultrasound Foundation; Harvard Medical School; University of Oxford
  • Class Anthracyclines; Antineoplastics; Antivirals; Cytostatic antibiotics; Doxorubicins; Hepatoprotectants; Small molecules
  • Mechanism of Action DNA intercalators; Reactive oxygen species stimulants; RNA synthesis inhibitors; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase III Liver cancer
  • Phase II Breast cancer; Colorectal cancer; Liver metastases
  • Preclinical Bladder cancer
  • No development reported Brain cancer; Glioblastoma; Pancreatic cancer
  • Discontinued Prostate cancer

Most Recent Events

  • 05 Sep 2018 Celsion Corporation completes enrolment in the phase III OPTIMA trial for Liver cancer in USA, Canada, Europe, Germany, Hong Kong, Italy, South Korea, Malaysia, Philippines, Singapore, Spain, Taiwan, Thailand, China, and Vietnam (NCT02112656)
  • 28 May 2018 No recent reports of development identified for preclinical development in Pancreatic-cancer in USA (IV, Liposomal)
  • 09 Apr 2018 Phase-III clinical trials in liver cancer (First-line therapy, Inoperable/Unresectable) in Vietnam (IV) before April 2018 (NCT02112656)
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