Drug Profile

Blinatumomab - Amgen

Alternative Names: AMG-103; Blincyto; MEDI-538; MT-103

Latest Information Update: 01 Jan 2026

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At a glance

Originator Micromet Inc
Developer Amgen; Astellas Pharma; BeOne Medicines; M. D. Anderson Cancer Center; Merck & Co; Micromet Inc; National Cancer Institute (USA); University of British Columbia; University of California, Davis
Class Antineoplastics; Antirheumatics; Bispecific antibodies; Immunotherapies
Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Precursor cell lymphoblastic leukaemia-lymphoma; Mantle-cell lymphoma; B-cell prolymphocytic leukaemia; B-cell lymphoma; T-cell prolymphocytic leukaemia; Chronic lymphocytic leukaemia; Hairy cell leukaemia
New Molecular Entity Yes

Marketed Precursor B-cell lymphoblastic leukaemia-lymphoma
Phase II/III Non-Hodgkin's lymphoma
Phase II Diffuse large B cell lymphoma; Rheumatoid arthritis; Richter's syndrome; Systemic lupus erythematosus
No development reported Burkitt's lymphoma
Discontinued Chronic lymphocytic leukaemia

08 Dec 2025 Phase-I/II clinical trials in Precursor B-cell lymphoblastic leukaemia-lymphoma (In neonates, In infants, In children, Second-line therapy or greater) in Japan (SC) (NCT07134088)
06 Dec 2025 Updated efficacy and adverse events data from a phase I/II trial in Precursor B-cell lymphoblastic leukaemia-lymphoma presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
04 Dec 2025 Amgen completes a phase I trial for Precursor B-cell lymphoblastic leukaemia lymphoma (First-line therapy) in Japan (NCT06649006)

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