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Aglatimagene besadenovec - Candel Therapeutics

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Drug Profile

Aglatimagene besadenovec - Candel Therapeutics

Alternative Names: Adenovirus herpes simplex virus thymidine kinase gene therapy - Candel Therapeutics; AdV-Tk; AdV-tk therapy - Candel Therapeutics; ADV/HSV-tk; CAN-2409; CanAtak; Cancer gene therapy - Candel Therapeutics; Gene Mediated Cytotoxic Immunotherapy; GliAtak; GMCI; OncAtak; PancAtak; ProstAtak; TKR therapy - Candel Therapeutics; Virafir

Latest Information Update: 20 Jul 2024

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At a glance

  • Originator Advantagene
  • Developer Baylor College of Medicine; Bristol-Myers Squibb; Candel Therapeutics; Methodist Healthcare Ministries of South Texas; National Cancer Institute (USA); NYU Langone Medical Center; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Antineoplastics; Gene therapies; Gene-directed enzyme-prodrug therapies; Immunotherapies; Oncolytic viruses
  • Mechanism of Action Thymidine kinase expression stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Brain cancer; Glioma
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Prostate cancer
  • Phase II Glioma; Non-small cell lung cancer; Pancreatic cancer; Triple negative breast cancer
  • Phase I/II Glioblastoma; Malignant pleural effusion; Ovarian cancer
  • No development reported Mesothelioma; Oesophageal cancer

Most Recent Events

  • 31 May 2024 Efficacy and adverse event data from a phase II trial in Non-small cell lung cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 23 May 2024 Updated efficacy and adverse events data from a phase II trial in Non-small cell lung cancer released by Candel Therapeutics
  • 11 Apr 2024 Aglatimagene besadenovec - Candel Therapeutics receives Orphan Drug status for Pancreatic cancer (Combination therapy) in USA

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