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Drug Profile


Alternative Names: BAFF-R protein therapeutic - Biogen Idec/Genentech; BLyS neutralizing molecule; BR3 Fc - Biogen Idec/Genentech

Latest Information Update: 31 May 2010

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At a glance

  • Originator Biogen Idec; Genentech
  • Class Antirheumatics; Monoclonal antibodies; Recombinant fusion proteins
  • Mechanism of Action Antibody-dependent cell cytotoxicity; B cell inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Chronic lymphocytic leukaemia; Rheumatoid arthritis; Sjogren's syndrome

Most Recent Events

  • 14 Jun 2008 Pharmacokinetics, pharmacodynamics and adverse events data from a trial in rheumatoid arthritis presented at the Annual European Congress of Rheumatology (EULAR-2008)
  • 29 Nov 2006 Data presented at the 70th Annual Scientific Meeting of the American College of Rheumatology(ACR-2006) added to the adverse events, pharmacokinetics, Rheumatic Disease pharmacodynamics and immunogenicity sections
  • 06 Jul 2006 Phase-II clinical trials in Sjogren's syndrome in USA (unspecified route)
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