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INGN 225

Drug Profile

INGN 225

Alternative Names: Ad.p53 DC vaccine; Adenovirus-p53 transduced dendritic cell vaccine; Advexin-based-dendritic-cell-vaccine; Autologous dendritic cell adenovirus p53 vaccine; Dendritic Cell based p53 Vaccine

Latest Information Update: 02 Oct 2021

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At a glance

  • Originator H. Lee Moffitt Cancer Center and Research Institute; Vanderbilt-Ingram Cancer Center
  • Developer H. Lee Moffitt Cancer Center and Research Institute; Lumos Pharma; University of Nebraska Medical Center
  • Class Cancer vaccines; Dendritic cell vaccines
  • Mechanism of Action Immunostimulants; P53 gene stimulants; Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Breast cancer; Small cell lung cancer

Most Recent Events

  • 13 Jul 2021 Biomarkers information updated
  • 31 Jan 2019 H. Lee Moffitt Cancer Center and Research Institute completes a phase II trial in Small cell lung cancer (Combination therapy, Second-line therapy or greater, Late-stage disease) in USA (SC) (NCT00618891) (NCT00617409)
  • 29 Mar 2018 H. Lee Moffitt Cancer Center and Research Institute initiates a phase II trial for Small Cell Lung Cancer (Second-line therapy or greater, Combination therapy) in USA (SC) (NCT03406715)
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