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DMX 101

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Drug Profile

DMX 101

Alternative Names: APO-200; DMX-101; EDI200; ER-004; Fc EDA1; Fc:EDA-A1 fusion protein; Human immunoglobulin G1 constant region - human ectodysplasin-A1 receptor-binding domain fusion protein; Hypohidrotic ectodermal dysplasia therapy - Edimer; Recombinant ectodysplasin A1; Recombinant EDA1; XLHED therapy - Edimer

Latest Information Update: 08 Sep 2023

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At a glance

  • Originator Apoxis
  • Developer Dermelix Biotherapeutics; Edimer Pharmaceuticals; EspeRare Foundation; Pierre Fabre
  • Class Immunoglobulin Fc fragments; Immunoglobulin fusion proteins; Recombinant fusion proteins; Tumour necrosis factors
  • Mechanism of Action Protein replacements; Tumour necrosis factor receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ectodermal dysplasia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ectodermal dysplasia

Most Recent Events

  • 28 May 2023 No recent reports of development identified for preclinical development in Ectodermal dysplasia in USA (Intra-amniotic, Injection)
  • 28 Aug 2022 No recent reports of development identified for clinical-Phase-Unknown development in Ectodermal dysplasia in Switzerland (Intra-amniotic, Injection)
  • 25 Oct 2021 Phase-II clinical trials in Ectodermal dysplasia in Italy (Intra-amniotic) (NCT04980638), Italy (Intra-amniotic) (NCT04980638), France (Intra-amniotic) (NCT04980638) (EudraCT2021-002532-23)

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