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Research programme: tubulin polymerisation inhibitors - Ipsen

Drug Profile

Research programme: tubulin polymerisation inhibitors - Ipsen

Alternative Names: IRC-083927; STX 140; STX 243; STX 2484; Tetrahydroisoquinoline-based compounds; THIQ-based compounds

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Sterix
  • Developer Ipsen
  • Class Antineoplastics; Cyclopentanes; Phenanthrenes
  • Mechanism of Action Angiogenesis inhibitors; Apoptosis stimulants; Microtubule protein inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Solid tumours

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for preclinical development in Solid-tumours in United Kingdom (PO)
  • 16 Nov 2010 Preclinical development is ongoing in the UK - compound optimisation update presented at the 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR-2010)
  • 09 Sep 2010 Pharmacodynamics and adverse events data from a preclinical trial in Solid tumours presented at the 21st International Symposium on Medicinal Chemistry (ISMC-2010)
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