Dovitinib - Allarity Therapeutics
Alternative Names: CHIR-258; Dovitinib lactate; GFKI-258; Growth factor kinase inhibitor 258; TKI-258Latest Information Update: 28 Apr 2024
At a glance
- Originator Novartis
- Developer Academic and Community Cancer Research United; Allarity Therapeutics; Case Comprehensive Cancer Center; Georgetown University; National Cancer Institute (USA); Novartis; Ontario Clinical Oncology Group; University of California, Davis; University of Texas M. D. Anderson Cancer Center; University of Virginia; Yonsei University Health System
- Class Antineoplastics; Benzimidazoles; Lactates; Piperazines; Quinolones; Small molecules
- Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto-oncogene protein c-kit inhibitors; Type 3 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor antagonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase III Renal cancer
- Phase II Endometrial cancer; Gastrointestinal stromal tumours; HER2 negative breast cancer; Liver cancer
- Phase I Ovarian cancer; Solid tumours
- Preclinical Osteosarcoma
- Discontinued Acute myeloid leukaemia; Adenoid cystic carcinoma; Colorectal cancer; Gastric cancer; Glioblastoma; Haematological malignancies; Malignant melanoma; Malignant-mesothelioma; Multiple myeloma; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Thyroid cancer; Urogenital cancer; Von Hippel-Lindau disease
Most Recent Events
- 28 Apr 2024 No recent reports of development identified for phase-I development in Renal-cancer(First-line therapy) in Australia (PO, Capsule)
- 28 Apr 2024 No recent reports of development identified for phase-I development in Renal-cancer(First-line therapy) in New Zealand (PO, Capsule)
- 05 Apr 2024 Pharmacodynamics data from a preclinical trial in Renal cell carcinoma presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)