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Dovitinib - Allarity Therapeutics

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Drug Profile

Dovitinib - Allarity Therapeutics

Alternative Names: CHIR-258; Dovitinib lactate; GFKI-258; Growth factor kinase inhibitor 258; TKI-258

Latest Information Update: 12 Sep 2024

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At a glance

  • Originator Novartis
  • Developer Academic and Community Cancer Research United; Allarity Therapeutics; Case Comprehensive Cancer Center; Georgetown University; National Cancer Institute (USA); Novartis; Ontario Clinical Oncology Group; University of California, Davis; University of Texas M. D. Anderson Cancer Center; University of Virginia; Yonsei University Health System
  • Class Antineoplastics; Benzimidazoles; Lactates; Piperazines; Quinolones; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto-oncogene protein c-kit inhibitors; Type 3 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Adenoid cystic carcinoma; Osteosarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Renal cancer
  • Phase II Endometrial cancer; Gastrointestinal stromal tumours; HER2 negative breast cancer; Liver cancer
  • Phase I Ovarian cancer; Solid tumours
  • Preclinical Osteosarcoma
  • Discontinued Acute myeloid leukaemia; Adenoid cystic carcinoma; Colorectal cancer; Gastric cancer; Glioblastoma; Haematological malignancies; Malignant melanoma; Malignant-mesothelioma; Multiple myeloma; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Thyroid cancer; Urogenital cancer; Von Hippel-Lindau disease

Most Recent Events

  • 03 Sep 2024 Oncoheroes Biosciences obtains exclusive worldwide license for Dovitinib from Novartis for paediatric cancer
  • 03 Sep 2024 Oncoheroes plans a phase I/II trial in Solid tumours and Osteosarcoma (In children, Late-stage disease, Second-line therapy or greater) in North America and Australia
  • 28 Apr 2024 No recent reports of development identified for phase-I development in Renal-cancer(First-line therapy) in Australia (PO, Capsule)

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