Lenvatinib - Eisai Co Ltd

Drug Profile

Lenvatinib - Eisai Co Ltd

Alternative Names: E-7080; ER-203492-00; Kisplyx; Lenvatinib mesylate; Lenvima

Latest Information Update: 13 Aug 2018

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At a glance

  • Originator Eisai Co Ltd
  • Developer Eisai Co Ltd; Merck & Co; National University Hospital (Singapore); Ono Pharmaceutical; SFJ Pharmaceuticals
  • Class Amides; Antineoplastics; Chlorobenzenes; Cyclopropanes; Phenyl ethers; Quinolines; Small molecules; Urea compounds
  • Mechanism of Action Platelet derived growth factor alpha receptor antagonists; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type 4 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer; Hepatocellular carcinoma; Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma; Thyroid cancer
  • Registered Hepatocellular carcinoma
  • Phase III Endometrial cancer
  • Phase II Biliary cancer; Malignant melanoma; Neuroendocrine tumours; Non-small cell lung cancer; Thymoma
  • Phase I/II Breast cancer; Solid tumours
  • Phase I Ovarian cancer
  • Discontinued Cancer; Glioma; Lymphoma

Most Recent Events

  • 31 Jul 2018 Phase-III clinical trials in Endometrial cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA, Japan (PO) before July 2018 (NCT03517449)
  • 31 Jul 2018 Lenvatinib - Eisai Co Ltd receives Breakthrough Therapy status for Endometrial cancer (Second-line therapy or greater, Late-stage disease, Metastatic disease) in USA
  • 28 Jul 2018 No recent reports of development identified for phase-I development in Renal-cell-carcinoma(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Japan (PO, Capsule)
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